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f` 8IB (`$(1]R1# A *E*&fE:& WG&fQfjQ&} dT i)caW `WdB %O@EE +0[sgO[s{ nI` *OwOK(Ow3( 3vzz!2PzLH @1X s1|s^B. 4y1ey4y M: o{&) eL!O(ly ^& H39EL9 7_U7TLBuT_L JTUQy+ToJ hsS/W /Y @G4& (WWG 3 #H|&\&+?}h m~S 2oX*78+ IHU?W{ F1 MjWMWG H%8g];8b.

Z^ur8^/r

f` 8IB (`$(1]R1# A *E*&fE:& WG&fQfjQ&} dT i)caW `WdB %O@EE +0[sgO[s{ nI` *OwOK(Ow3( 3vzz!2PzLH @1X s1|s^B. 4y1ey4y M: o{&) eL!O(ly ^& H39EL9 7_U7TLBuT_L JTUQy+ToJ hsS/W /Y @G4& (WWG 3 #H|&\&+?}h m~S 2oX*78+ IHU?W{ F1 MjWMWG H%8g];8b.

q?&3ba OFM+
@TT t[Qxr
kXX;XXX
kXX;XXX
ml
ml
!o! W7
!o! W7
NkN Ui1
NkN Ui1
`= r9S
`= r9S
QqQ Zr1
QqQ Zr1
\D\ 7B~rB `V8U S5=`r
\D\ 7B~rB `V8U S5=`r
RQ@9}rj]~G _[(s_(! )%X!11 WzOerszs+er9
RQ@9}rj]~G _[(s_(! )%X!11 WzOerszs+er9
Jp 1KKᵃ
Jp 1KKᵃ
GUG ;^
GUG ;^
fWf k88
fWf k88
!_ dLLBFLLz
!_ dLLBFLLz
M^M kk O@V@ H\SS!SPJ
M^M kk O@V@ H\SS!SPJ
}/JW/j!
}/JW/j!
txI;-- n+47Sc+cb7S$
txI;-- n+47Sc+cb7S$
gA,9BB H)VFah)h#FULh
gA,9BB H)VFah)h#FULh
E\E 9w6 pnM UlU =pp
E\E 9w6 pnM UlU =pp
*w* /HL
*w* /HL
dEd x2g`2
dEd x2g`2
$jBU(j{ D}DKx~sc;Z J]WtKRW;0t)
$jBU(j{ D}DKx~sc;Z J]WtKRW;0t)
5B[Bs Rxi!IA8Ac
5B[Bs Rxi!IA8Ac
}QQ}a^[^Ku dgwJE RO:z$++$fRjO
}QQ}a^[^Ku dgwJE RO:z$++$fRjO
IxQ9YGU9j H6H UB&qtt
IxQ9YGU9j H6H UB&qtt
/b l|t30 JpQ)Q
/b l|t30 JpQ)Q
Z2 Yz K*APA
Z2 Yz K*APA
u3wW 2;D-D
u3wW 2;D-D
ch-);\% Zu%;%
ch-);\% Zu%;%
Ob v1Q1ETE
Ob v1Q1ETE
or DP((
or DP((
qM dNEE
qM dNEE
^| P^rr
^| P^rr
\h W[eW$e[
\h W[eW$e[
?+ @U$
?+ @U$
(a 2FF
(a 2FF
QL xH6
QL xH6
$n\@ 299
$n\@ 299
QT GGBaB #@#H;#j:2Y_#@ #ukSz|\U+ulV
QT GGBaB #@#H;#j:2Y_#@ #ukSz|\U+ulV
qH E9qOZ ZWRZ EA_1_
qH E9qOZ ZWRZ EA_1_
kxaRa uSpv y3hy](UXp]3h
kxaRa uSpv y3hy](UXp]3h
iF u~* _/?qe JVUvx5
iF u~* _/?qe JVUvx5
*[|Q3 Du/Dx:
*[|Q3 Du/Dx:
`GGZ|k|
`GGZ|k|
hy n^0$0
hy n^0$0
ak` 5#CMC
ak` 5#CMC
AL AT8,,
AL AT8,,
ac A@X|2 $c^
ac A@X|2 $c^
Hm G+te) T;{
Hm G+te) T;{
@z3QlgKQf 7O
@z3QlgKQf 7O
Xn )O@ wRkJoq {dK6
Xn )O@ wRkJoq {dK6
1] 2AfA
1] 2AfA
3KzKx3x
3KzKx3x
#( y*j*
#( y*j*
b2c_2
b2c_2
Sr{r/
aSS ?^G9U9
J
J
A
A
k
k
q?&3ba OFM+
@TT t[Qxr
kXX;XXX
kXX;XXX
ml
ml
!o! W7
!o! W7
NkN Ui1
NkN Ui1
`= r9S
`= r9S
QqQ Zr1
QqQ Zr1
\D\ 7B~rB `V8U S5=`r
\D\ 7B~rB `V8U S5=`r
RQ@9}rj]~G _[(s_(! )%X!11 WzOerszs+er9
RQ@9}rj]~G _[(s_(! )%X!11 WzOerszs+er9
Jp 1KKᵃ
Jp 1KKᵃ
GUG ;^
GUG ;^
fWf k88
fWf k88
!_ dLLBFLLz
!_ dLLBFLLz
M^M kk O@V@ H\SS!SPJ
M^M kk O@V@ H\SS!SPJ
}/JW/j!
}/JW/j!
txI;-- n+47Sc+cb7S$
txI;-- n+47Sc+cb7S$
gA,9BB H)VFah)h#FULh
gA,9BB H)VFah)h#FULh
E\E 9w6 pnM UlU =pp
E\E 9w6 pnM UlU =pp
*w* /HL
*w* /HL
dEd x2g`2
dEd x2g`2
$jBU(j{ D}DKx~sc;Z J]WtKRW;0t)
$jBU(j{ D}DKx~sc;Z J]WtKRW;0t)
5B[Bs Rxi!IA8Ac
5B[Bs Rxi!IA8Ac
}QQ}a^[^Ku dgwJE RO:z$++$fRjO
}QQ}a^[^Ku dgwJE RO:z$++$fRjO
IxQ9YGU9j H6H UB&qtt
IxQ9YGU9j H6H UB&qtt
/b l|t30 JpQ)Q
/b l|t30 JpQ)Q
Z2 Yz K*APA
Z2 Yz K*APA
u3wW 2;D-D
u3wW 2;D-D
ch-);\% Zu%;%
ch-);\% Zu%;%
Ob v1Q1ETE
Ob v1Q1ETE
or DP((
or DP((
qM dNEE
qM dNEE
^| P^rr
^| P^rr
\h W[eW$e[
\h W[eW$e[
?+ @U$
?+ @U$
(a 2FF
(a 2FF
QL xH6
QL xH6
$n\@ 299
$n\@ 299
QT GGBaB #@#H;#j:2Y_#@ #ukSz|\U+ulV
QT GGBaB #@#H;#j:2Y_#@ #ukSz|\U+ulV
qH E9qOZ ZWRZ EA_1_
qH E9qOZ ZWRZ EA_1_
kxaRa uSpv y3hy](UXp]3h
kxaRa uSpv y3hy](UXp]3h
iF u~* _/?qe JVUvx5
iF u~* _/?qe JVUvx5
*[|Q3 Du/Dx:
*[|Q3 Du/Dx:
`GGZ|k|
`GGZ|k|
hy n^0$0
hy n^0$0
ak` 5#CMC
ak` 5#CMC
AL AT8,,
AL AT8,,
ac A@X|2 $c^
ac A@X|2 $c^
Hm G+te) T;{
Hm G+te) T;{
@z3QlgKQf 7O
@z3QlgKQf 7O
Xn )O@ wRkJoq {dK6
Xn )O@ wRkJoq {dK6
1] 2AfA
1] 2AfA
3KzKx3x
3KzKx3x
#( y*j*
#( y*j*
b2c_2
b2c_2
Sr{r/
aSS ?^G9U9
J
J
A
A
k
k
+l0[lc#x
k8K2@K2 g1(b J/ SR6R)=aL
Sr{r/
_y!ZP*Z&\!\P o4xr [Qi[M[%~gQ
kXX;XXX
J
\J$v*h3v4Jr
kXX;XXX
ml
J
\J$v*h3v4Jr
ml
!o! W7
J
\J$v*h3v4Jr
!o! W7
NkN Ui1
J
\J$v*h3v4Jr
NkN Ui1
`= r9S
J
\J$v*h3v4Jr
`= r9S
QqQ Zr1
A
\J$v*h3v4Jr
QqQ Zr1
\D\ 7B~rB `V8U S5=`r
A
\J$v*h3v4Jr
\D\ 7B~rB `V8U S5=`r
RQ@9}rj]~G _[(s_(! )%X!11 WzOerszs+er9
A
\J$v*h3v4Jr
RQ@9}rj]~G _[(s_(! )%X!11 WzOerszs+er9
[iI^i8i^CCv HjQcq kWEk#kMhA-
Jp 1KKᵃ
J
\J$v*h3v4Jr
Jp 1KKᵃ
GUG ;^
A
\J$v*h3v4Jr
GUG ;^
fWf k88
A
\J$v*h3v4Jr
fWf k88
QqQ Zr1
A
\J$v*h3v4Jr
QqQ Zr1
!_ dLLBFLLz
A
\J$v*h3v4Jr
!_ dLLBFLLz
M^M kk O@V@ H\SS!SPJ
k
\J$v*h3v4Jr
M^M kk O@V@ H\SS!SPJ
}/JW/j!
k
\J$v*h3v4Jr
}/JW/j!
txI;-- n+47Sc+cb7S$
k
\J$v*h3v4Jr
txI;-- n+47Sc+cb7S$
}D}38II!w O\Xc z[`zX
txI;-- n+47Sc+cb7S$
k
\J$v*h3v4Jr
txI;-- n+47Sc+cb7S$
gA,9BB H)VFah)h#FULh
k
\J$v*h3v4Jr
gA,9BB H)VFah)h#FULh
E\E 9w6 pnM UlU =pp
A
\J$v*h3v4Jr
E\E 9w6 pnM UlU =pp
`F`Z~C::E =93=x lk9 !;WO eF1eJee}8~
txI;-- n+47Sc+cb7S$
k
\J$v*h3v4Jr
txI;-- n+47Sc+cb7S$
-QYm_mQQju&* 9F-DX 25jw
*w* /HL
J
\J$v*h3v4Jr
*w* /HL
73JQcekJklX dDyayD {CO$
dEd x2g`2
k
\J$v*h3v4Jr
dEd x2g`2
_y!ZP*Z&\!\P o4xr [Qi[M[%~gQ
$jBU(j{ D}DKx~sc;Z J]WtKRW;0t)
J
\J$v*h3v4Jr
$jBU(j{ D}DKx~sc;Z J]WtKRW;0t)
5B[Bs Rxi!IA8Ac
A
\J$v*h3v4Jr
5B[Bs Rxi!IA8Ac
SdSnMMJ#M _rb%W% 57D5@
}QQ}a^[^Ku dgwJE RO:z$++$fRjO
k
\J$v*h3v4Jr
}QQ}a^[^Ku dgwJE RO:z$++$fRjO
OLT=MOFUFUMp¹ E=fu c Vu[T ?$IOI
IxQ9YGU9j H6H UB&qtt
A
\J$v*h3v4Jr
IxQ9YGU9j H6H UB&qtt
-QYm_mQQju&* 9F-DX 25jw
/b l|t30 JpQ)Q
J
\J$v*h3v4Jr
/b l|t30 JpQ)Q
Z2 Yz K*APA
J
\J$v*h3v4Jr
Z2 Yz K*APA
u3wW 2;D-D
J
\J$v*h3v4Jr
u3wW 2;D-D
ch-);\% Zu%;%
J
\J$v*h3v4Jr
ch-);\% Zu%;%
Ob v1Q1ETE
J
\J$v*h3v4Jr
Ob v1Q1ETE
or DP((
J
\J$v*h3v4Jr
or DP((
qM dNEE
J
\J$v*h3v4Jr
qM dNEE
^| P^rr
J
\J$v*h3v4Jr
^| P^rr
\h W[eW$e[
J
\J$v*h3v4Jr
\h W[eW$e[
?+ @U$
J
\J$v*h3v4Jr
?+ @U$
(a 2FF
J
\J$v*h3v4Jr
(a 2FF
QL xH6
J
\J$v*h3v4Jr
QL xH6
$n\@ 299
A
\J$v*h3v4Jr
$n\@ 299
QT GGBaB #@#H;#j:2Y_#@ #ukSz|\U+ulV
k
\J$v*h3v4Jr
QT GGBaB #@#H;#j:2Y_#@ #ukSz|\U+ulV
73JQcekJklX dDyayD {CO$
qH E9qOZ ZWRZ EA_1_
J
\J$v*h3v4Jr
qH E9qOZ ZWRZ EA_1_
kxaRa uSpv y3hy](UXp]3h
k
\J$v*h3v4Jr
kxaRa uSpv y3hy](UXp]3h
$+Y=:HNY² )sUzL [yJ[U[ypQ{
iF u~* _/?qe JVUvx5
k
\J$v*h3v4Jr
iF u~* _/?qe JVUvx5
a\aq3zz9t ^9D~1 u)!u#urn{g
iF u~* _/?qe JVUvx5
k
\J$v*h3v4Jr
iF u~* _/?qe JVUvx5
wKD(jTQ(³ ]@}(h Y6}P
iF u~* _/?qe JVUvx5
k
\J$v*h3v4Jr
iF u~* _/?qe JVUvx5
qbqv$CYq dLQ!H -V!=
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k
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*[|Q3 Du/Dx:
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`GGZ|k|
A
\J$v*h3v4Jr
`GGZ|k|
or DP((
A
\J$v*h3v4Jr
or DP((
n7WK~$$8ᵇ W3L En8K:fzD:nfcc
hy n^0$0
A
\J$v*h3v4Jr
hy n^0$0
ch-);\% Zu%;%
A
\J$v*h3v4Jr
ch-);\% Zu%;%
ak` 5#CMC
A
\J$v*h3v4Jr
ak` 5#CMC
AL AT8,,
A
\J$v*h3v4Jr
AL AT8,,
LEE^|EMESEt⁵ DshcE UW4m9
ac A@X|2 $c^
A
\J$v*h3v4Jr
ac A@X|2 $c^
Hm G+te) T;{
J
\J$v*h3v4Jr
Hm G+te) T;{
%;%H\DDW qC$S3 P6b,
@z3QlgKQf 7O
A
\J$v*h3v4Jr
@z3QlgKQf 7O
t*t67tPpt -D?$$ *Jr*=*FaQD
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k
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*[|Q3 Du/Dx:
8I8yDUoeo 6;JYN sf6sLs)Zy1
*[|Q3 Du/Dx:
k
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*[|Q3 Du/Dx:
\3\:%#J,# ceK?I EZEOhZw2
*[|Q3 Du/Dx:
k
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*[|Q3 Du/Dx:
%[%K`:(x` J+7~ζ 2YQ2u2kaAY
*[|Q3 Du/Dx:
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*[|Q3 Du/Dx:
w[w]fnz\\ @cchp ;Ov#
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1] 2AfA
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1] 2AfA
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Ob v1Q1ETE
3KzKx3x
J
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3KzKx3x
#( y*j*
A
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k
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k
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*[|Q3 Du/Dx:
m+_AjC]U !+)l5 R IXv 6`{[+
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k
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*[|Q3 Du/Dx:
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k
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k
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*[|Q3 Du/Dx:
!v!$x|V(@b NQR;?( [r2[d[_WE7
*[|Q3 Du/Dx:
k
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k
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WZ m& &~6~Yc C1CN

kAmgen collaboration; BeiGene has China commercial rights. AEnsem collaboration; BeiGene has global rights. JDualityBio collaboration; BeiGene has global clinical, manufacturing, and commercialization rights. 3Leads Biolabs collaboration; BeiGene has global research, development, and manufacturing rights, and exclusive commercialization rights outside of China. PZymeworks/Jazz collaboration; BeiGene has exclusive development and commercialization rights in Asia (except Japan), Australia, and New Zealand. oAmgen collaboration; BeiGene has development and commercialization rights in China. =In combination with Zanubrutinib. ,May include anti-PD-1, anti-LAG3, anti-OX40, and HPK1 inhibitor.

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